Ecological association between indoor radon concentration and childhood leukaemia incidence in France, 1990-1998.
نویسندگان
چکیده
The objective of this study was to evaluate the ecological association between indoor radon concentration and acute leukaemia incidence among children under 15 years of age in the 348 geographical units (zones d'emploi, ZE) of France between 1990 and 1998. During that period, 4015 cases were registered by the French National Registry of Childhood Leukaemia and Lymphoma. Exposure assessment was based on a campaign of 13 240 measurements covering the whole country. The arithmetic mean radon concentration was 85 Bq/m (range, 15-387 Bq/m) and the geometric mean, 59 Bq/m (range: 13-228 Bq/m). A positive ecological association, on the borderline of statistical significance (P=0.053), was observed between indoor radon concentration and childhood leukaemia incidence. The association was highly significant for acute myeloid leukaemia (AML) (P=0.004) but not for acute lymphocytic leukaemia (ALL) (P=0.49). The standardized incidence ratio (SIR) increased by 7, 3 and 24% for all acute leukaemia, ALL and AML, respectively, when radon concentration increased by 100 Bq/m. In conclusion, the present ecological study supports the hypothesis of a moderate association between indoor radon concentration and childhood acute myeloid leukaemia. It is consistent with most previous ecological studies. Since the association is moderate, this result does not appear inconsistent with the five published case-control studies, most of which found no significant association.
منابع مشابه
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Introduction The leukemogenic effect of ionising radiation has been well established for high-dose exposure. In contrast, the risk associated with natural radiation exposure still needs to be documented. Ecological studies have suggested a positive association between indoor radon concentration and childhood leukaemia, which has not been confirmed by case-control studies. The studies that inves...
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ورودعنوان ژورنال:
- European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
دوره 14 2 شماره
صفحات -
تاریخ انتشار 2005